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Ciriolo, Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology

38 These detoxification-related proteins promote metabolic inactivation of APAP, thus protecting the liver from damage induced by NAPQI (Figure 2)

Rybelsus commonly causes nausea, vomiting, and abdominal discomfort, particularly during the initial weeks of treatment